Corroborating the fact that the inflammatory response and oxidative stress has an important role in the hearing loss, studies demonstrated that the use of glucocorticoids, antioxidants, and JNK inhibitors, which can alter various points in programmed cell death pathways [15], as well as anti-TNFα agents, showed good response in noise-induced hearing loss [8]. Here, MAPK8 is linked to hearing loss disorder.