A part of sera from CRC patients including stage I and II were positive for CD147, although both CEA and CA19-9 positive serum could not be found in those patients [68]; (ii) ExoTest found an increase in plasma exosomes expressing CD63 and caveolin-1 in melanoma patients; (iii) ExoQuick is an efficient method for the isolation of exosomes compared to ultracentrifugation and is suitable to obtain a good yield of exosomal miRNA an mRNA from serum and urine, as exosomal miR-191, miR-21, and miR-451a as potential early diagnostic markers in pancreatic cancer [62]. This evidence concerns the gene CEACAM5 and pancreatic neoplasm.