In multivariate analysis, both increased RBM8A expression (HR=0.470, 95%CI=0.322−0.871; P<0.0018) and lymph node metastasis (HR=3.271, 95%CI=2.873−4.002; P<0.001) induced worse prognosis independently (Table 2). This evidence concerns the gene RBM8A and metastatic malignant neoplasm in the lymph nodes.