In the present research, we described histopathological changes, viral dissemination, glial reaction, and expression of TNFα, TGF-β, INF-γ, IL-6, IL-10, IL-12p40, IL-12p70, MCP-1, and NO in the brains of young adult mice after Maraba virus-induced meningoencephalitis. This evidence concerns the gene TNF and meningoencephalitis.