In our study, we found DM patients-derived ADSCs and AGEs-induced ADSCs showed a decreased wound healing ability, in mechanism, we confirmed biological activity of HIF-1α was impaired in DM patients-derived ADSCs and AGEs-induced ADSCs than in normal ADSCs, while CITED2 was upregulated and miR-1248 restrain the expression of CITED2. This evidence concerns the gene HIF1A and diabetes mellitus.