Nevertheless, and consistent with our findings, many CMT2 patients carrying mutations in the orthologous genes for fzo-1, unc-116, lin-41, hsp-25 and osm-9 have been reported to exhibit muscular atrophy and myopathy especially in the distal limbs [1, 47–52]. This evidence concerns the gene TRIM71 and Charcot-Marie-Tooth disease type 2.