Patients with higher levels of total bilirubin had the following characteristics: older (p = 0.012), more males (p<0.001), lower serum albumin levels (p<0.001), more with hyponatremia (p<0.001), longer prothrombin time (p<0.001), more metabolic acidosis (p<0.001), fewer cerebrovascular attacks (p<0.001), more cirrhosis (p<0.001), more hepatoma (p<0.001), fewer lung cancer (p<0.001), more shocks (p<0.001), more peritonitis (p<0.001), more ascites (p<0.001), and more gastrointestinal bleeding (p<0.001). This evidence concerns the gene F2 and metabolic acidosis.