CD274 and neoplasm: In these samples, the percentage of PD-L1+ cells increased in the metastatic/recurrent site compared to the primary tumour in 6 of 9 cases (67%), from which 3 cases had only a modest increase (i.e. 1% to 5 or to 10%; Table 1) but a dramatic increase was identified in the 3 remaining cases (Fig 3).