Interestingly, the distribution of UICC stages showed that there was a significant difference in the expression of the Ubqln2 protein only between the HCC early stages (stage i and stage ii) and advanced stages (stage iii and stage iv) (Figure 1E), whereas there were no significant differences in differentiation and vascular invasion between the high and low Ubqln2 expression groups (Figure 1F,G). Here, UBQLN2 is linked to hepatocellular carcinoma.