High expression of Ubqln2 contributed approximately 78 points to the total points, which was more points than those contributed by moderate pathological stage, tumor size less than 10 cm, intrahepatic metastasis and vascular invasion, indicating that Ubqln2 plays a more important role than the other risk factors in the prognosis of patients with HCC. Here, UBQLN2 is linked to hepatocellular carcinoma.