Analysis of the relationship between Ubqlns expression and clinicopathologic characteristics demonstrated that Ubqln4 has no relation with clinicopathologic characteristics in HCC patients (Table S2), and Ubqln1 was only correlated with distant metastasis (Table S1), while Ubqln2 was significantly associated with poor clinicopathologic characteristics including UICC tumor stage (Pearson χ2 test, P = .022), UICC stage (Pearson χ2 test, P = .034) as well as resection potential (Pearson χ2 test, P = .017) in the TCGA cohort (Table 1). This evidence concerns the gene UBQLN1 and neoplasm.