INS and Alzheimer disease: GO analysis showed that several AD-associated biological processes were reduced including cellular response to hyperoxia and insulin stimulus, synaptic transmission, and positive regulation of autophagy (Fig. 2b, Supplementary Table S4), while ventricular septum morphogenesis, negative regulation of protein ubiquitination, and protein homooligomerization were induced in AD-associated biological processes (Fig. 2b, Supplementary Table S5).