To observe the differential chromatin accessibility in APP/PS1 mice associated with gene expression, we examined 740 chromatin-accessible regions in AD with 43 upregulated associated genes and identified several genes with a notable increasing expression, including Sele, Clec7a, Cst7, Ccr6, and CD300lf, which may have profound significance in the AD process. Here, CD300LF is linked to Alzheimer disease.