Thus, we investigated the histone modifications in open chromatin regions of the most upregulated genes in AD mice, including Sele, Ccr6, CD300lf, Clec7a, and Cst7. The results showed that four of the five most upregulated genes, except for CD300lf, displayed a higher level for both H3K4me3 and H3K27ac marks in chromatin-accessible gene regions in the hippocampus of AD model mice than in WT mice. The gene discussed is SELE; the disease is Alzheimer disease.