APP and Alzheimer disease: In this work, we used the Assay for Transposase-Accessible Chromatin by sequencing (ATAC-seq), a sensitive tool for integrative epigenomic analysis, combined with RNA sequencing (RNA-seq) to investigate the pattern of genome-wide chromatin accessibility in AD in an APP/PS1 mouse model, which resembles the familial AD in humans, and characterize the chromatin accessibility landscape in APP/PS1 mice.