There was no significant difference in circulating Gal-9 between patients with and without clinical remission (10,647 pg/ml [IQR 6960–13,367] versus 8635 pg/ml [IQR 6372–10,092], p = 0.703) in RA patients with high titers of ACPA (≧ 200 U/ml). This evidence concerns the gene PRTN3 and rheumatoid arthritis.