In RA patients low titers of ACPA (< 200 U/ml), circulating Gal-9 were significantly higher in patients without clinical remission compared to those with clinical remission (8252 pg/ml [IQR 5870–10,996] versus 7103 pg/ml [IQR 5328–8357], p = 0.013). The gene discussed is LGALS9; the disease is rheumatoid arthritis.