In contrast, there was no significant difference in circulating Gal-9 between those with and without advanced articular lesions (stage II–IV) in RA patients with high titers of ACPA (10,146 pg/ml [IQR 8771–12,257] versus 5882 pg/ml [IQR 5053–8138], p = 0.182) (Fig. 6b). The gene discussed is PRTN3; the disease is rheumatoid arthritis.