However, there was no correlation between circulating Gal-9 and these parameters (r = 0.203, p = 0.249 and r = 0.160, p = 0.365) in RA patients with high titers of ACPA (≧ 200 U/ml) (Fig. 4a, b). The gene discussed is PRTN3; the disease is rheumatoid arthritis.