Moreover, we found that sFRP1 from NE-stimulated HSCs augments an autocrine feedback loop of Wnt16B/β-catenin signaling in HCC cells by increasing the interaction of Wnt16B with the receptor FZD7 and enhancing Wnt16B expression, thereby inducing cell migration, invasion, EMT, and expression of proliferation-related markers and cancer stem cell markers to promote HCC progression. Here, SFRP1 is linked to hepatocellular carcinoma.