TLR4 and type 2 diabetes mellitus: Decreased expression level of CTBP1-AS2 was closely correlated with the occurrence of type 2 diabetes and cardiomyocyte hypertrophy among Iranian population [12]., Luo et al. reported that CTBP1-AS2 could be induced by Sp1 and it could stabilize TLR4 through the interaction with FUS to participate in the disease progression [13].