A loop of has-circ-0028198/has-circ-0092317/XIST/miR-543/aspartate beta-hydroxylase or has-circ-0028198/has-circ-0092317/XIST/miR-543/phosphodiesterase 3B has been implicated in oxidized, low-density, lipoprotein-stimulated foam cells in atherosclerosis [24]. The gene discussed is ASPH; the disease is atherosclerosis.