In order to investigate whether the exosomes from CAFs transmit miR-93-5p to regulate FOXA1 gene and affect irradiation resistance in CRC, the nude mice were then subcutaneously implanted with cells that were cultured with serum-free medium containing agomir-NC-exo or agomir-93-5p-exo and subjected to irradiation. Here, FOXA1 is linked to colorectal carcinoma.