In the hippocampus, IκBα (main effect of challenge (F(3,20) = 10.13, p < 0.01), Fig. 7i) and the IL6/IL10 ratio (F(3,20) = 13.06, p < 0.01, Fig. 7j), increased in both diet groups, while CD11B decreased in CHD females (main effect of challenge (F(3,20) = 4.456, p < 0.05), Scheffe post hoc p = 0.047) and no change was seen in HFD offspring (Scheffe post-hoc p = 0.909, Fig.7k). Here, ITGAM is linked to coronary artery disorder.