APOA1 and myocardial infarction: Current studies are focused on improving the functions of HDL particles, with one of them, CSL-112, a recombinant apolipoprotein A-I undergoing Phase 3 clinical trials in patients with myocardial infarction to see the effect on major adverse cardiac events (MACE), after Phase 2b trials having shown large increases in efflux capacity with this drug [27, 28].