However, the cutoff value of NT-proBNP to predict the adverse outcome of severe COVID-19 patients was far lower than the threshold to diagnose heart failure (450 pg/mL for < 50 years, 900 pg/mL for 50–75 years and 1800 pg/mL for > 75 years) [12] in present study. This evidence concerns the gene NPPB and COVID-19.