NR1I2 and cholestasis: Analysis of IPA canonical pathways showed that the top 10 canonical pathways in descending order of –log (p-value) score were G-protein coupled receptor signaling, LPS/IL-1 mediated inhibition of RXR function, glucocorticoid receptor signaling, cAMP-mediated signaling, AMPK signaling, eNOS signaling, hepatic cholestasis, xenobiotic metabolism signaling, PXR/RXR activation and LXR/RXR activation.