The Cancer Genome Atlas (TCGA) with comprehensive genetic profiling of 279 HNSCC specimens demonstrated that EGFR, CCND1, PIK3CA, and FGFR1 amplifications and TP53, CDKN2A, and HRAS mutations are common genetic alterations in HNSCC [36]. Here, TP53 is linked to head and neck squamous cell carcinoma.