The Cancer Genome Atlas (TCGA) with comprehensive genetic profiling of 279 HNSCC specimens demonstrated that EGFR, CCND1, PIK3CA, and FGFR1 amplifications and TP53, CDKN2A, and HRAS mutations are common genetic alterations in HNSCC [36]. The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.