With respect to CD44, it has been reported that modulation of CD44 is detrimental to CSCs self-renewal and differentiation and NSCLC cells expressing CD44 are enriched for stem-like properties, suggesting that ALDH1A1bright/CD44high CSCs linked to tumor progression and EGFR-TKI resistance is associated with a significantly poor prognosis factor in NSCLC [14, 31]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.