Combinatorial treatment of retinoids with EGFR-TKIs drugs in EGFR-TKIs resistance lung cancer cells promotes the activation of GATA6 and then inhibits the activation of EGFR/Wnt signaling pathways and favors the association of RXR, RARβ, and cellular retinoic acid binding protein-2 (CRABP2). The gene discussed is CRABP2; the disease is lung cancer.