YAP1 and posterior cortical atrophy: In a study by Zhang et al., the YAP1 mRNA was associated with androgen-insensitive PCa cells (LNCaP-C81 and LNCaP-C4–2 cells) compared with the level in androgen-sensitive LNCaP cells, and YAP1 confers castration resistance in vivo [32], strongly suggesting that YAP1 expression was associated with aggressive-phenotype PCa, particularly in the treatment-resistant stage.