CELSR2 and hepatocellular carcinoma: The functional networks of neighboring genes close to CELSR2 are generally involved in cell adhesion and intercellular interaction processes, and mainly functioned through adhesion-related signaling pathways, which was consistent with previous studies [33–35]; meanwhile, they also worked through carcinogenic signaling pathways e.g., the classic Hippo signaling pathway in HCC [36–38].