As shown in Fig. 2a, the gene expression of CELSR2 in liver tissue was lower than that in other normal tissues (liver/other normal: logFC = − 2.10), and CELSR2 expression in HCC was lower than that in other tumor tissues (HCC/all tumor: logFC = − 2.16), which were consistent with results in the HPA (Fig. 1a, b). This evidence concerns the gene CELSR2 and neoplasm.