Thenafter, differential expression levels of CELSR2 were detected in 12 different HCC datasets, and the results showed that in most datasets (9/12), such as HCCDB1, HCCDB3, HCCDB4, HCCDB6, HCCDB7, HCCDB13, HCCDB15, HCCDB17 and HCCDB18, the gene expression of CELSR2 in HCC was much higher than that in adjacent liver tissues (Fig. 2b). The gene discussed is CELSR2; the disease is hepatocellular carcinoma.