Yuchen Jiao, et al. [4] identified that ICC patients with IDH1/2 mutation had 3-year overall survival of 33% compared to 81% for patients with IDH1/2 wild-type (P = 0.0034), but Pu Wang, et al. [7] showed IDH1/2 mutation was significantly associated with improved prognosis in ICCs (4-years tumor recurrence rate was 45.3% vs. 71.5%; P = 0.046). The gene discussed is IDH1; the disease is intrahepatic cholangiocarcinoma.