For instance, uniquely up-regulated miR-23a correlates with several mitochondrial proteins including G6PC and PPARGC1. Several miRs, particularly, miR-181d and miR-576, correlate with cell cycle genes including BCL2 and CCND1. BCL2, a major regulator of mitochondrial apoptosis, has been consistently shown to be down regulated in colon (and cancer) [46]. This evidence concerns the gene PPARGC1A and cancer.