Previously published methylation markers including SEPT9, VIM, GATA4, INA, MAL, WNT (WNT2/2B/3/6/5A/7A, APC2) and CNRIP1 are hypermethylated in both RSCC and LSCC [58, 59], further establishing them as side-agnostic methylation markers of CRC. The gene discussed is APC2; the disease is colorectal carcinoma.