For instance, dysregulation of WNT/β-catenin pathway genes affecting proliferative potential of CRC is evident in both, with the upregulation of several WNT pathway genes including AXIN2, WNT2, WNT3, WNT7B, DKK1/4, NKD1/4, TCF7, MYC and NOTUM. NOTUM, a glypican-dependent WNT inhibitor serves as a negative feedback regulator for WNT activation [25], and is associated with the progression of CRC [26]. This evidence concerns the gene NOTUM and colorectal carcinoma.