Transcription from euchromatic genes such as Sgs8 and Act5c was not affected; however the Hsp70Aa gene was upregulated in the null and dADD1a overexpression conditions and this effect seems to be independent on the presence of HP1a, this places dADD1 proteins as regulators of this chaperone which has also been observed to be over-expressed in different types of cancers [56]. Here, CBX5 is linked to cancer.