ABCA1 and ischemic stroke: More recently, a meta-analysis was carried out in the Asian and Caucasian populations and have found that homozygous RR of R219K was significantly associated with increased IS risk (OR = 1.31, 95% CI: 1.16-1.48; p<0.001) [30], which is consistent with our finding that ABCA1 KK+RK carriers might have decreased risk of ischemic stroke.