Finally, we found that co-culture of tumor-antigen P1A-specific P1CTL cells (Bai et al., 2003) with IL-27 in vitro resulted in significant upregulation of CXCR3 in P1CTL cells (Figure 4F), suggesting that IL-27 can directly induce CXCR3 in tumor-specific T cells. The gene discussed is CXCR3; the disease is neoplasm.