Among the CD45+ population, CD3+, CD4+, CD8+ T cells, and CD3–CD49b+ NK cells had increased (Supplementary Figure S2B and Figure 3C), and tumor infiltrating CD4+ and CD8++T cells produced more IFN-γ in AAV-IL-27 treated tumors (Supplementary Figure S3A and Figure 3D). Here, CD4 is linked to neoplasm.