IL5 and asthma: They effect Th2 cell function either directly or via innate lymphoid cells (ILCs), which in turn produce IL-5, IL-9, and IL-13 (Licona-Limon et al., 2013; Scadding, 2014), related to Th2-type CRS, asthma and AR (Toppila-Salmi et al., 2015).