Reportedly, HSPH1 (Yang et al., 2015), APC2 (Ghosh et al., 2016), CHST4 (Gao et al., 2015), HGF (Unic et al., 2018), MTHFD2 (Liu et al., 2016), and AGO3 (Kitagawa et al., 2013) are closely related to HCC. This evidence concerns the gene CHST4 and hepatocellular carcinoma.