Reportedly, HSPH1 (Yang et al., 2015), APC2 (Ghosh et al., 2016), CHST4 (Gao et al., 2015), HGF (Unic et al., 2018), MTHFD2 (Liu et al., 2016), and AGO3 (Kitagawa et al., 2013) are closely related to HCC. The gene discussed is HSPH1; the disease is hepatocellular carcinoma.