Reportedly, HSPH1 (Yang et al., 2015), APC2 (Ghosh et al., 2016), CHST4 (Gao et al., 2015), HGF (Unic et al., 2018), MTHFD2 (Liu et al., 2016), and AGO3 (Kitagawa et al., 2013) are closely related to HCC. Here, MTHFD2 is linked to hepatocellular carcinoma.