We identified that CRYAB (AUC = 0.7472, P < 0.001), ECM1 (AUC = 0.8100, P < 0.001) and GPX3 (AUC = 0.6714, P = 0.010) can be applied in differential diagnosis between HGBC and LGBC, while CRNN (AUC = 0.5891, P = 0.179) and CGNL1 (AUC = 0.5411, P = 0.536) can't (Figure 2C). This evidence concerns the gene CRYAB and Hemoglobin C Measurement.