The results suggested that expressions of GPX3 (AUC = 0.8794, P = 0.0001), ECM1 (AUC = 0.9794, P < 0.0001), CRYAB (AUC = 0.9216, P < 0.0001), and CGNL1 (AUC = 0.9765, P < 0.0001) have good predictive power for diagnosis of HGBC, indicating that they may be used as an urine biomarker for HGBC. The gene discussed is GPX3; the disease is Hemoglobin C Measurement.