Then we found that ECM1 (extracellular matrix protein 1), CRYAB (alpha B-crystallin), CGNL1 (cingulin-like 1), and GPX3 (glutathione peroxidase 3) are correlated with diagnosis, progression, metastasis and prognosis of HGBC. This evidence concerns the gene CRYAB and Hemoglobin C Measurement.