The Cancer Genome Atlas (TCGA) database comprising 963 breast carcinoma samples mainly derived from invasive tumours (93.2%) and Metabric with a total of 2173 breast cancer samples (76.4% from invasive tumours) were used (via the online cBioPortal portal) following a molecular analysis to compare genetic characteristics of SYK and the well-known tumour suppressors TP53 and PTEN in samples from invasive breast cancer. This evidence concerns the gene PTEN and breast cancer.