SYK and diffuse large B-cell lymphoma: On one side, B-cell receptor signalling has been associated with survival signals in malignancies of B cell origins, and as a consequence a number of SYK inhibitors have entered clinical development for the treatment of B-cell malignancies, including entospletinib [7] and TAK-659, although very recent data from a Phase II study in refractory diffuse large B-cell lymphoma suggests that efficacy of the relatively unselective SYK inhibitor, fostamatinib, was poor [8].