A number of studies have suggested a negative regulatory role of SYK in the control of cell proliferation, migration and invasion in breast cancer cell lines [9, 10], that allelic deletion of SYK is associated with higher incidences of breast cancer [12], and that loss of SYK expression through promoter hypermethylation is associated with increased invasiveness of breast cancer cells [13]. Here, SYK is linked to breast carcinoma.