In one study, its knockdown was shown to inhibit histone H3 lysine 27 (H3K27me3) from associating with the Wnt promoter, thereby blocking the gene expression of Wnt1 and Wnt10, and inhibiting adipogenesis 49 In mice with diet-induced obesity, GSK126, an Ezh2-specific inhibitor, rescued the obese phenotype by promoting the differentiation of thermogenic beige adipocytes 50. Here, EZH2 is linked to obesity due to melanocortin 4 receptor deficiency.