In Fudan LCI cohort 1, the clinicopathological analysis indicated that SLFN11 expression negatively correlated with high levels of serum alpha-fetoprotein (AFP; P < 0.001), a marker widely used to detect HCC, large tumor size (P = 0.005), presence of microvascular invasion (P = 0.025), advanced Barcelona Clinic Liver Cancer (BCLC) stage (P = 0.038), and advanced tumor-nodes-metastasis (TNM) stage (P = 0.030) (Table S1). This evidence concerns the gene AFP and hepatocellular carcinoma.