CD44 and neoplasm: The HA-NPs could selectively internalize with CD44 receptors overexpressed on B16F10 melanoma cancer cells and tumor vascular endothelial cells to prompt preferential intracellular delivery of pDNA payloads, and block the CD44-angiogenic signaling for pursuit of inhibited tumorigenesis, leading to effective ablation of primary tumor and lung metastasis.