Therapy using hyperthermia and 131I led to a strongly reduced tumor growth, prolonged survival with reduced blood vessel density and proliferation index, demonstrating the long-term antiangiogenic therapeutic efficacy of 131I. At normothermic conditions (37 °C), treatment with HSP70B-NIS-MSCs followed by 131I application resulted in slightly reduced tumor growth (22% showed a response to the therapy). Here, SLC5A5 is linked to neoplasm.