The results of our ChIP sequencing (ChIP-seq) assays revealed the presence of peaks in the core autophagy genes Atg5, Atg2A, Atg4C, Atg7, Atg13, Atg16L1, Atg101, AMBRA1, DRAM2 and Ulk1, suggesting that REV-ERBα may directly bind to the promoters of autophagy genes in SCLC cells (Figure 6A). This evidence concerns the gene AMBRA1 and small cell lung carcinoma.