NR1D1 and small cell lung carcinoma: Furthermore, we examined the expression of Atg5 in the abovementioned SCLC subcutaneous tumor models through immunohistochemistry (IHC), which also showed that Atg5 expression was blocked in the SR9009-treated group (Figure 6D), whereas the expression of this gene was induced following depletion of REV-ERBα by siRNA(Figure 6E and F).