In this study, we found that c-Myc could interact directly with PRMT5 to transcriptionally repress the expression of a cohort of genes, including PTEN, CDKN2C (p18INK4C), CDKN1A (p21CIP1/WAF1), CDKN1C (p57KIP2) and p63, to promote gastric cancer cell growth (Figure 6E). This evidence concerns the gene CDKN1A and gastric cancer.