The PRMT5-mediated H4R3me2s mark is enriched on c-Myc-binding CANNTG E-box elements and acts together with c-Myc to selectively repress expression of a cohort of largely cell cycle-related genes, including PTEN, CDKN2C (p18INK4C), CDKN1A (p21CIP1/WAF1), CDKN1C (p57KIP2) and p63, to promote gastric cancer cell growth. The gene discussed is PTEN; the disease is gastric cancer.