CDKN2B and gastric cancer: Interestingly, two prototypical Myc-repressed genes, CDKN1B (p27KIP1) and CDKN2B (p15INK4B) 39, 46, 53, 54, showed no response to manipulation of c-Myc in the context of gastric cancer (Figure 2A), strengthening the concept that c-Myc regulates gene expression selectively and specifically.