Previously, miR-128 was reported to participate in the regulation of inflammatory related diseases, such as RA 15 and OA 18, inflammatory signaling, like NF-κB 15 and TNF-α 16, and ox-LDL-incubated RAW264.7 17, which raises the possibility that miR-128 participates in the regulation of osteoclastogenesis and osteoporosis. This evidence concerns the gene TNF and rheumatoid arthritis.