Since the ectopic overexpression of SRGN and incubation with CM-SRGN promoted chemoresistance in BC cells and the YAP-TEAD1 complex regulated SRGN expression via positive feedback, we sought to determine whether SRGN also regulated the YAP-mediated chemoresistance and cancer stem cell (CSC) status via YAP-TEAD1 interaction. The gene discussed is SRGN; the disease is breast cancer.