For example, blood group A subjects have been found to have higher levels of total cholesterol and low-density lipoprotein cholesterol.18 Another possible mechanism for the association of blood groups A and non-O could be increased expression of inflammatory molecules such as tumor necrosis factor alpha which is known to mediate endothelial cell activation by increasing the expression of various adhesion molecules.17 All these reports show the possible mechanism linking ABO gene locus with the risk of CAD. Here, TNF is linked to coronary artery disorder.