Kominato et al. had described that hypermethylation of ABO gene promoter caused silencing of the gene in stomach carcinoma cell line.5 Later Bianco-Miotto et al., reported that hypermethylation of ABO promoter was associated with the loss of ABO allelic expression in patients with leukemia.25 Therefore, the current study is unique in reporting the association of higher methylation of ABO gene promoter to the risk of AMI in a Pakistani population. This evidence concerns the gene ABO and leukemia.