A systematic review by Chen et al., 2016 has shown an association of blood group A and non O blood groups with increased risk of coronary artery disease (CAD).2 A recent report from China indicated that blood group A was an independent risk factor for severity of CAD.3 These reports show that expression of ABO gene has an indirect relationship with the development of CAD. The gene discussed is ABO; the disease is coronary artery disorder.