The relative complications and high expenses of gold standard test utilized for the diagnosis of NAFLD has insisted the field to pursuit for more diagnostic methods.4 Evidence based researches have suggested that serum biomarkers including serum AST, ALT and CK18 have a remarkable role in early detection of the liver diseases.5 Elevation of serum transaminase levels in NAFLD patients has been well documented by previous studies. The gene discussed is KRT18; the disease is metabolic dysfunction-associated steatotic liver disease.