Intriguingly, tumor IGF1R expression is associated with lymphatic invasion and predicts shorter progression-free survival in EGFR-mutant but not EGFR–wild type NSCLC, suggesting a unique interplay between EGFR and IGF1R pathways in this type of malignancy (Park et al., 2015). This evidence concerns the gene EGFR and non-small cell lung carcinoma.