To identify candidate mediators of SCLC transformation, Niederst et al. used genomic sequencing to compare the molecular profiles of EGFR TKI resistant-NSCLC and EGFR TKI resistant-SCLC samples that were obtained from a single patient who was initially diagnosed with EGFR-mutant LUAD (Niederst et al., 2015). Here, EGFR is linked to non-small cell lung carcinoma.