Still, results from human (Kukkonen et al., 2010) and animal (Frossard et al., 2004) studies indicate that IgA might play an important role for tolerance development, and alterations in IgA coating patterns of intestinal bacteria have been associated with multiple disorders including atopic diseases (Dzidic et al., 2017) and IBD (Van Der Waaij et al., 2004), although the results are ambiguous. Here, CD79A is linked to inflammatory bowel disease.