ITPR2 and benign neoplasm: FUNDC1, via binding to the ER-resident inositol 1,4,5-trisphosphate type 2 receptor (IP3R2), modulates Ca2+ release from the ER at mitochondria-associated ER membranes (MAMs) to maintain mitochondrial function and homeostasis, which is essential for cardiac function, and to protect the heart from failure (Wu et al., 2017).