PRKN and diabetic cardiomyopathy: Similarly, SIRT3 catalyzes the acetylation of Forkhead box protein O (FOXO) 3, which is upstream of Parkin-dependent mitophagy (Celestini et al., 2018), to maintain mitochondrial homeostasis during streptozotocin-induced diabetic cardiomyopathy in vivo (Das et al., 2014).