At the same time, the high dose of esculetin can regulate the PTEN/Akt signaling pathway and inhibit the phosphorylation of Akt, leading to attenuated expression of Snail and Twist to inhibit the migration of PC3 cells in prostate cancer (Turkekul et al., 2018).In this study, transcriptomics was used to identify proteins that were differentially expressed in the total protein incubated with its active compound or not. This evidence concerns the gene AKT1 and prostate carcinoma.