ALDH2 and heart disorder: Previous studies have suggested that ALDH2 plays a central protective role in several types of cardiac diseases and global cellular oxidative stress mainly through metabolizing various aldehydes, such as 4-hydroxy-2-nonenal (4-HNE) which is the most abundant and reactive carbonyl species (Chen et al., 2014; Ji et al., 2016; Liu et al., 2018).