Synaptotagmin 11 (Syt11), a substrate for ubiquitinylation by parkin, is one of the risk genes for Parkinson's disease; overexpression (resulting from parkin dysfunction) leads to impaired dopamine release, degeneration of dopaminergic neurons, and associated motor behavioral deficits (Wang et al., 2018a). The gene discussed is SYT11; the disease is Parkinson disease.