MGMT and neoplasm: 1. decrease proliferation; G2/M cell cycle arrest; deplete MGMT; reversed MGMT mediated TMZ-resistance; apoptosis via inhibition of Akt/mTOR pathway; cell cycle arrest2. inhibit proliferation; delay migration3. G2/M cell cycle arrest, increase apoptosis; suppress cyclin D1, bcl-xl, p-Akt genes, suppress NF-Kb, VEGF, HSP 70; reduced intracranial tumor volume