GRIA1 and glioblastoma: Excitation of AMPA-activated classes of ionotropic glutamate receptors (GluA1 to 4) augments the cell migration and proliferation of human glioblastoma cells (Ishiuchi et al., 2002), mediated in part by Ca2+-dependent activation of a survival factor Akt kinase, as confirmed in surgical samples and in glioblastoma cell lines (Ishiuchi et al., 2007).