1.Inhibit IL-6 mediated JAK/STAT3 signaling pathway(dose dependent); reduce proliferation and migration2.increase sensitivity of GBM lines to TMZ by suppression of heat shock protein 27 (Hsp27)3. increase caspase-3 & -7 proteolytic activity; induce autophagy (dose dependent); apoptosis. The gene discussed is STAT3; the disease is glioblastoma.