Constant or prolonged light exposure was reported to have a series of actions, such as brain development, psychosocial and emotional disorders, reproductive failure, biliary hyperplasia and liver fibrosis, increased oxidative stress and loss of circadian rhythms in locomotor activity, energy metabolism and insulin sensitivity (Tapia-Osorio et al., 2013; Alves-Simoes et al., 2016; Benedetto and Contin, 2019; Chen et al., 2019; Datta et al., 2019; Fobert et al., 2019; Haraguchi et al., 2019). This evidence concerns the gene INS and Hepatic fibrosis.