In HGPS patients’ fibroblasts, it was shown that accumulation of progerin in the nuclear lamina causes alterations in the repressive histone mark H3K27me3 distribution, and in the associations between heterochromatin and nuclear lamina, which ultimately results in a global loss of chromatin compartmentalization (McCord et al., 2013). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.